Autoantibody Against Plasma Thromboplastin Antecedent Associated With Multiple Apparent Plasma Clotting Factor Deficiencies in a Patient With Systemic Lupus Erythematosus
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چکیده
A 42-yr-old woman with systemic lupus erythematosus without bleeding diathesis developed a prolonged activated partial thromboplastin time that was not corrected by normal plasma. An inhibitor that acted rapidly and mactivated 0.5 U/mI plasma thromboplastin antecedent (PTA. factor Xl) at a 1 :200 plasma dilution was demonstrated. In addition to a low titer of PTA (<0.01 U/mI). plasma assayed at 20-fold dilution also showed low titers of Hageman (factor XII. 0.02 U/mI). Fletcher (plasma prekallikrein, 0.02 U/mI). and Fitzgerald (high molecular weight kininogen. <0.01 U/mI) factors. The titer of these factors. except PTA. returned to normal upon further plasma dilution or upon removal of the inhibitor by protein A adsorption. Thus. the inhibitor appeared to interfere with these clotting factor assays. possibly by inactivating PTA in the substrate plasmas in the test system. Its specificity was further confirmed. The inhibitor did not interfere with
منابع مشابه
A unique precipitating autoantibody against plasma thromboplastin antecedent associated with multiple apparent plasma clotting factor deficiencies in a patient with systemic lupus erythematosus.
A 42-yr-old woman with systemic lupus erythematosus without bleeding diathesis developed a prolonged activated partial thromboplastin time that was not corrected by normal plasma. An inhibitor that acted rapidly and inactivated 0.5 U/ml plasma thromboplastin antecedent (PTA, factor XI) at a 1:200 plasma dilution was demonstrated. In addition to a low titer of PTA (less than 0.01 U/ml), plasma a...
متن کاملStudies on a circulating anticoagulant in systemic lupus erythematosus: evidence for inhibition of the function of activated plasma thromboplastin antecedent (factor XIa).
Plasma proteins which interfere with blood coagulation have often been described in patients with systemic lupus erythematosus (SLE). The most frequent type interferes with the conversion of prothrombin to thrombin and thus prolongs the prothrombin time. Infrequently, SLE patients exhibit anticoagulants which appear to block the earlier stages of coagulation such as those involving factor VIII ...
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Fitzgerald factor ( high molecular weight kininogen) is an agent in normal human plasma that corrects the impaired in vitro surface-mediated plasma reactions of blood coagulation, fibrinolysis, and kinin generation observed in Fitzgerald trait plasma. To assess the possible pathophysiologic role of Fitzgerald factor, its titer was measured by a functional clot-promoting assay. Mean ± SD in 42 n...
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